Description

4-(4-Halophenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride is a versatile and high-value pharmaceutical intermediate, primarily utilized in the synthesis of complex active pharmaceutical ingredients (APIs). Its core value lies in its role as a critical building block for central nervous system (CNS) targeting drugs, enabling the development of new therapeutic agents. This compound is essential for research and development chemists, process chemists, and manufacturers in the global pharmaceutical and fine chemical industries seeking reliable, high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of piperidine-based drug candidates and active pharmaceutical ingredients (APIs).
• Central Nervous System (CNS) Drug Research: Used in the development of novel therapeutics targeting neurological disorders.
• Medicinal Chemistry & R&D: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to introduce the 4-(halophenyl)-1,2,3,6-tetrahydropyridine moiety into more complex molecules.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial APIs.
• Academic Research: Utilized in university and institutional laboratories for pharmacological studies and novel synthetic route development.

Basic Information

Product Name	4-(4-Halophenyl)-1,2,3,6-Tetrahydro-pyridine Hydrochloride
CAS No.	1978-59-2
Molecular Formula	C12H15ClN • HCl (for chloro derivative)
Molecular Weight	244.17 g/mol (for chloro derivative)
Synonyms	4-(4-Chlorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride; 4-(p-Chlorophenyl)-1,2,3,6-tetrahydropyridine HCl; 4-(4-Halophenyl)-1,2,3,6-tetrahydro-pyridine HCl; 1,2,3,6-Tetrahydro-4-(4-chlorophenyl)pyridine hydrochloride; 4-(4-Chlorophenyl)-3,6-dihydro-2H-pyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(4-Halophenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.