Description

Trifluoromethanesulfonic Acid Difluoromethyl Ester is a versatile fluorinated organic building block and reagent. This compound is valued for its unique reactivity profile, enabling the introduction of the difluoromethoxyl group into target molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its properties make it a key intermediate for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethoxyl group can improve biological activity and environmental profile.
• Material Science: Serves as a monomer or modifier in the creation of specialty polymers and coatings with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in laboratories as a specialized reagent for nucleophilic substitution and coupling reactions to introduce fluorine-containing motifs.
• Liquid Crystal & Electronic Chemicals: Potential use as a precursor in the synthesis of fluorinated liquid crystals and dielectric fluids for the electronics industry.

Basic Information

Product Name	Trifluoromethanesulfonic Acid Difluoromethyl Ester
CAS No.	1885-46-7
Molecular Formula	C2HF5O3S
Molecular Weight	200.09 g/mol
Synonyms	Difluoromethyl Trifluoromethanesulfonate; Difluoromethyl Triflate; (Difluoromethoxy)sulfur Trifluoride Oxide; Trifluoromethanesulfonic Acid, Difluoromethyl Ester; Methyl Difluoride Trifluoromethanesulfonate; F3CSO2OCHF2
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, purity, and impurity profiles. We maintain strict adherence to cGMP principles where applicable. Certificates of Analysis (COA) are available upon request and provide full traceability and detailed analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its nature as a strong acid/organic solvent and highly volatile compound, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture ingress and evaporation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.