Description

4-Fluoroestradiol is a fluorinated derivative of the endogenous hormone estradiol, distinguished by the substitution of a fluorine atom at the 4-position of the steroid A-ring. This structural modification significantly alters its biological activity and metabolic profile, making it a compound of high interest in advanced pharmaceutical research and development. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in endocrinology, oncology, and the development of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for method development, validation, and quality control in the synthesis of fluorinated steroid-based drugs.
• Biochemical Research: Used as a molecular probe to study the structure-activity relationships (SAR) of estrogen receptors (ERα and ERβ) and the impact of halogenation on receptor binding affinity.
• Metabolic Studies: Employed in preclinical research to investigate the pharmacokinetics, metabolic pathways, and stability of fluorinated steroid analogs compared to their non-fluorinated counterparts.
• Drug Discovery & Development: Acts as a key intermediate or active pharmaceutical ingredient (API) precursor in the R&D pipeline for novel anticancer agents, particularly for hormone-responsive cancers.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry, steroid biochemistry, and nuclear hormone receptor biology.

Basic Information

Product Name	4-Fluoroestradiol
CAS No.	1881-37-4
Molecular Formula	C18H23FO2
Molecular Weight	290.37 g/mol
Synonyms	4-Fluoroestra-1,3,5(10)-triene-3,17β-diol; 4-Fluoro-17β-estradiol; 4-F-E2; 4-Fluoro-E2; 4-Fluoroestradiol-17β; 17β-Hydroxy-4-fluoroestra-1,3,5(10)-trien-3-ol
EINECS	Contact for details

Quality Control

Our 4-Fluoroestradiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.