Description

o-tert-Butyl-n-Carbobenzoxy-L-Serine Methyl Ester is a protected amino acid derivative, specifically a serine derivative, that serves as a crucial chiral building block in advanced organic synthesis. Its primary value lies in providing a versatile, stereochemically defined scaffold for constructing complex peptide and peptidomimetic structures. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of active pharmaceutical ingredients (APIs), peptide-based therapeutics, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate protected serine residues into peptide chains.
• Protease Inhibitor Development: Serves as a core structural component in the research and production of serine protease inhibitors.
• Bioconjugation & Labeling: Employed in the preparation of peptide conjugates for diagnostic applications, drug delivery systems, and biochemical probes.
• Chemical Biology Research: Utilized as a tool compound for studying enzyme mechanisms, protein-protein interactions, and signal transduction pathways.
• Academic & R&D Laboratories: A standard reagent for methodological development in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	o-tert-Butyl-n-Carbobenzoxy-L-Serine Methyl Ester
CAS No.	1872-59-9
Molecular Formula	C16H23NO5
Molecular Weight	309.36 g/mol
Synonyms	N-Carbobenzoxy-O-tert-butyl-L-serine methyl ester; Cbz-Ser(OtBu)-OMe; Z-Ser(OtBu)-OMe; Nα-(Benzyloxycarbonyl)-O-tert-butyl-L-serine methyl ester; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-((tert-butoxy)oxy)propanoate; L-Serine, N-[(phenylmethoxy)carbonyl]-O-(1,1-dimethylethyl)-, methyl ester; Z-L-Ser(OtBu)-OMe
EINECS	Contact for details

Quality Control

Our o-tert-Butyl-n-Carbobenzoxy-L-Serine Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.