Description

n-(Benzyloxycarbonyl)-L-Serine 4-Nitrophenyl Ester CAS NO 1676-91-1 is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is specifically designed to facilitate the controlled coupling of L-serine residues while protecting the reactive side chain hydroxyl group. It is an essential reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical reagent for the sequential addition of L-serine in automated and manual peptide assembly.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for the production of custom peptides and peptide fragments.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of complex peptide-based drug candidates and therapeutic agents.
• Bioconjugation and Labeling: The activated ester moiety is useful for attaching peptides to other molecules, surfaces, or probes in bioconjugation strategies.
• Research & Development: Employed in academic and industrial R&D labs for exploring new peptide structures and studying structure-activity relationships (SAR).
• Production of Protected Peptide Segments: Used for the preparation of fully or partially protected peptide segments for subsequent fragment condensation.

Basic Information

Product Name	n-(Benzyloxycarbonyl)-L-Serine 4-Nitrophenyl Ester
CAS No.	1676-91-1
Molecular Formula	C17H16N2O7
Molecular Weight	360.32 g/mol
Synonyms	Z-Ser-ONp; Cbz-L-Serine 4-Nitrophenyl Ester; N-Carbobenzoxy-L-serine p-nitrophenyl ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-hydroxypropanoic acid 4-nitrophenyl ester; Nα-Cbz-L-serine p-nitrophenyl ester; Benzyloxycarbonyl-L-serine p-nitrophenyl ester; L-Serine, N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our n-(Benzyloxycarbonyl)-L-Serine 4-Nitrophenyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]D20: Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.