Description

n-Cbz-L-Serine Methyl Ester is a protected amino acid derivative widely used as a key chiral building block in organic synthesis. This compound is essential for the controlled introduction of the serine side chain while protecting the amine and carboxylic acid functionalities from unwanted reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of peptides, peptidomimetics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptide-based drugs.
• Bioconjugation Reagent: Used in the preparation of antibody-drug conjugates (ADCs) and other bioconjugates where a serine linker is required.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of serine protease inhibitors and other enzyme-targeted compounds.
• Chemical Biology Research: Employed in the synthesis of modified amino acids and probes for studying protein structure and function.
• Material Science: Used in the creation of specialized polymers and biomaterials that incorporate amino acid motifs.

Basic Information

Product Name	n-Cbz-L-Serine Methyl Ester
CAS No.	1676-81-9
Molecular Formula	C12H15NO5
Molecular Weight	253.25 g/mol
Synonyms	Carbobenzoxy-L-serine methyl ester; Cbz-Ser-OMe; N-Carbobenzyloxy-L-serine methyl ester; (S)-Methyl 2-(((benzyloxy)carbonyl)amino)-3-hydroxypropanoate; Benzyl N-[(1S)-2-hydroxy-1-(methoxycarbonyl)ethyl]carbamate; L-Serine, N-[(phenylmethoxy)carbonyl]-, methyl ester; Z-L-Serine methyl ester; Z-Ser-OMe
EINECS	Contact for details

Quality Control

Our n-Cbz-L-Serine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in methanol)
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Melting Point	78°C - 82°C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.