Description

Methoxycarbonylglycine 4-Nitrophenyl Ester is a specialized active ester derivative of glycine, widely utilized as a key synthetic building block in peptide coupling and amide bond formation. Its high reactivity with amine groups makes it an essential reagent for researchers and manufacturers developing novel pharmaceutical intermediates and fine chemicals. This compound is particularly valuable for organic synthesis chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors seeking efficient and selective acylation agents.

Application

• Peptide Synthesis: Serves as a protected glycine derivative for the controlled, stepwise construction of peptide chains in solid-phase and solution-phase synthesis.
• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing glycine or modified amino acid motifs.
• Bioconjugation & Probe Development: Used to label biomolecules (e.g., proteins, antibodies) with reporter groups or linkers via its reactive 4-nitrophenyl ester moiety.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, and plant growth regulators that incorporate amino acid derivatives.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating functionalized polymers with pendant amine-reactive groups.
• Chemical Biology: Facilitates the study of enzyme mechanisms and protein function through the introduction of stable acyl groups.

Basic Information

Product Name	Methoxycarbonylglycine 4-Nitrophenyl Ester
CAS No.	1670-94-6
Molecular Formula	C10H10N2O6
Molecular Weight	254.20 g/mol
Synonyms	Glycine, N-[(4-nitrophenoxy)carbonyl]-, methyl ester; Methyl N-[(4-nitrophenoxy)carbonyl]glycinate; 4-Nitrophenyl N-Methoxycarbonylglycinate; N-Carbomethoxyglycine p-Nitrophenyl Ester; p-Nitrophenyl N-Methoxycarbonylglycinate; N-Methoxycarbonylglycine p-Nitrophenyl Ester; (4-Nitrophenoxy)carbonylglycine Methyl Ester; Methyl (4-nitrophenoxycarbonylamino)acetate
EINECS	Contact for details

Quality Control

Our Methoxycarbonylglycine 4-Nitrophenyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive (store away from light). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.