Description

2,2,2-Trifluoroethanesulfonyl Chloride is a versatile and highly reactive organofluorine building block, primarily valued for its role as a key trifluoromethylsulfonylation reagent. Its importance lies in its ability to introduce the robust and lipophilic triflyl (Tf) group into target molecules, a critical transformation in modern synthetic chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients, and in materials science for creating advanced functional polymers.

Application

• Pharmaceutical Intermediate: A crucial reagent for the synthesis of trifluoromethanesulfonamide (triflamide) derivatives, which are key motifs in numerous active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that benefit from the metabolic stability imparted by the trifluoromethylsulfonyl group.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Ligand and Catalyst Preparation: Employed to synthesize sophisticated ligands for transition metal catalysis, particularly in asymmetric synthesis and cross-coupling reactions.
• Organic Synthesis Reagent: Acts as a powerful electrophile for introducing the Tf group onto nucleophiles like amines and alcohols, creating sulfonamides and sulfonate esters.
• Materials Science Research: Used in the development of novel ionic liquids, electrolytes for batteries, and other advanced materials requiring fluorinated sulfonyl components.

Basic Information

Product Name	2,2,2-Trifluoroethanesulfonyl Chloride
CAS No.	1648-99-3
Molecular Formula	C2H2ClF3O2S
Molecular Weight	182.55 g/mol
Synonyms	2,2,2-Trifluoroethanesulfonic Acid Chloride; Trifluoroethanesulfonyl Chloride; 2,2,2-Trifluoroethylsulfonyl Chloride; α,α,α-Trifluoroethanesulfonyl Chloride; Triflyl Chloride (common); TfCl; TFESC; 1,1,1-Trifluoro-2-chloroethanesulfonyl Chloride
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethanesulfonyl Chloride is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place, away from heat sources and incompatible materials such as strong bases, amines, and alcohols. Due to its highly volatile and reactive nature, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.