Description

5-Fluoro-6-Hydroxynicotinic Acid is a high-purity fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a hydroxyl group on a fluorinated pyridine ring, makes it an invaluable intermediate for creating complex molecules with targeted biological activity. This compound is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Ligand and Chelator Development: Serves as a precursor for synthesizing specialized ligands used in catalysis and metal complexation studies.
• Material Science Research: Employed in the development of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to build fluorescent tags or molecular probes for studying biological processes.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring fluorinated heterocycles.

Basic Information

Product Name	5-Fluoro-6-Hydroxynicotinic Acid
CAS No.	1526-16-5
Molecular Formula	C6H4FNO3
Molecular Weight	157.10 g/mol
Synonyms	6-Hydroxy-5-fluoronicotinic acid; 5-Fluoro-6-hydroxy-3-pyridinecarboxylic acid; 3-Pyridinecarboxylic acid, 5-fluoro-6-hydroxy-; 5-Fluoro-6-hydroxypyridine-3-carboxylic acid; 1526-16-5; 5-F-6-OH-Nicotinic Acid; 5-Fluoro-6-OH-Pyridine-3-Carboxylic Acid; 5-Fluoro-6-hydroxynicotinate
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-6-Hydroxynicotinic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.