Description

Ethyl 2-Fluoroacetoacetate is a versatile fluorinated building block, an ester derivative of fluoroacetoacetic acid, essential for introducing fluorine atoms into complex molecular frameworks. Its high reactivity and fluorine moiety make it a critical intermediate for synthesizing compounds with enhanced biological activity, metabolic stability, and material properties. This product is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to manufacture advanced fluorinated herbicides, fungicides, and pesticides, where the fluorine atom improves efficacy and environmental persistence.
• Fluorinated Heterocycle Construction: Serves as a versatile reagent for building fluorinated pyrazoles, isoxazoles, and other nitrogen- or oxygen-containing heterocycles.
• Material Science Research: Employed in developing novel fluorinated polymers, liquid crystals, and electronic materials with unique dielectric and surface properties.
• Chemical Biology & Proteomics: Acts as a starting material for creating fluorinated probes, tags, and enzyme inhibitors used in mechanistic studies and drug discovery.
• Custom Synthesis & Contract Manufacturing: A fundamental raw material for fine chemical and CDMO (Contract Development and Manufacturing Organization) facilities serving global innovation pipelines.

Basic Information

Product Name	Ethyl 2-Fluoroacetoacetate
CAS No.	1522-41-4
Molecular Formula	C6H9FO3
Molecular Weight	148.13 g/mol
Synonyms	Ethyl 2-fluoro-3-oxobutanoate; 2-Fluoroacetoacetic Acid Ethyl Ester; Ethyl fluoroacetoacetate; 3-Oxobutan-2-fluoroic acid ethyl ester; Acetoacetic acid, 2-fluoro-, ethyl ester; Ethyl α-fluoroacetoacetate; F-AAE; FAE
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-Fluoroacetoacetate is produced and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and documentation suitable for regulated industry use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its properties as a strong acid/organic solvent and high volatility, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent evaporation and moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.410 - 1.420
Density (g/mL, 20°C)	1.15 - 1.25

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.