Description

Methyl Chlorodifluoroacetate is a versatile fluorinated building block and reagent essential for advanced organic synthesis. This compound matters for its ability to introduce the difluoroacetate moiety, a key functional group in the development of pharmaceuticals and agrochemicals. Industries that need it include pharmaceutical R&D for creating novel active ingredients, agrochemical manufacturers for next-generation crop protection agents, and specialty chemical producers for high-value intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl or trifluoromethyl groups.
• Agrochemical Synthesis: Used in the production of modern herbicides, fungicides, and insecticides where fluorination enhances biological activity and environmental stability.
• Fluorinated Building Block: Serves as a versatile reagent in organic chemistry for the introduction of the -OCOCF2Cl group into target molecules.
• Material Science Research: Employed in the development of fluorinated polymers, coatings, and specialty materials with unique properties.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists exploring new synthetic pathways and compound libraries.

Basic Information

Product Name	Methyl Chlorodifluoroacetate
CAS No.	1514-87-0
Molecular Formula	C3H3ClF2O2
Molecular Weight	144.50 g/mol
Synonyms	Chlorodifluoroacetic Acid Methyl Ester; Methyl 2-Chloro-2,2-difluoroacetate; Difluorochloracetic Acid Methyl Ester; Methyl Chlorodifluoroethanoate; 2-Chloro-2,2-difluoroacetic Acid Methyl Ester; MCFA; Methyl Chlorodifluoroacetate; Methyl α,α-Difluoro-α-chloroacetate
EINECS	Contact for details

Quality Control

Our Methyl Chlorodifluoroacetate is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. Certificates of Analysis (COA) are provided with every shipment and are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and maintain product integrity. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.40 g/mL
Boiling Point	~90-95°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.