Description

Methyl L-Histidinate is a high-purity derivative of the essential amino acid L-Histidine, specifically the methyl ester. This compound is valued for its role as a key chiral building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of complex drug molecules, particularly peptides and histamine-related compounds.
• Biochemical Research: Used as a substrate or standard in enzymatic studies and metabolic pathway investigations.
• Peptide Synthesis: Serves as a protected amino acid derivative for solid-phase and solution-phase peptide chemistry.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Cosmetic & Nutraceutical R&D: Investigated for potential applications in advanced skincare formulations and bioactive supplements.

Basic Information

Product Name	Methyl L-Histidinate
CAS No.	1499-46-3
Molecular Formula	C7H11N3O2
Molecular Weight	169.18 g/mol
Synonyms	L-Histidine methyl ester; Methyl (2S)-2-amino-3-(1H-imidazol-4-yl)propanoate; Histidine methyl ester; H-His-OMe; Methyl L-Histidinate dihydrochloride (salt form); (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid methyl ester; Methyl α-amino-1H-imidazole-4-propanoate
EINECS	Contact for details

Quality Control

Our Methyl L-Histidinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for research and synthesis. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.