Description

4-Trifluoromethylpenylisocyanate is a specialized organic building block characterized by its reactive isocyanate group and trifluoromethyl substituent. This compound matters for its role in synthesizing advanced materials and active pharmaceutical ingredients, where the introduction of fluorine atoms can dramatically alter properties like metabolic stability and lipophilicity. It is needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated moieties to improve bioavailability and metabolic resistance.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Polymer & Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and adhesives with unique chemical resistance and surface properties.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for electronic display technologies, contributing to improved stability and performance.
• Chemical Research & Development: A valuable tool for medicinal and synthetic chemists exploring structure-activity relationships and developing new fluorinated compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific fluorinated isocyanate derivatives under cGMP or research-grade conditions.

Basic Information

Product Name	4-Trifluoromethylpenylisocyanate
CAS No.	1465-65-4
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	4-(Trifluoromethyl)phenyl isocyanate; 1-Isocyanato-4-(trifluoromethyl)benzene; p-Trifluoromethylphenyl isocyanate; α,α,α-Trifluoro-p-tolyl isocyanate; 4-Trifluoromethylphenyl isocyanate; 4-Trifluoromethylbenzenisocyanate; NSC 404088; p-(Trifluoromethyl)phenyl isocyanate
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylpenylisocyanate is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, acids, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.