Description

n-Tfa-L-Valine Methyl Ester is a protected amino acid derivative, specifically the methyl ester of N-trifluoroacetyl-L-valine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceuticals, offering high purity and stereochemical integrity. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for advanced organic synthesis and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis as a protected valine residue, where the TFA group offers orthogonal protection strategies.
• Proteomics Research: Serves as a reagent in biochemical research for studying protein structure, function, and enzyme mechanisms.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecular architectures.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, agrochemicals, and advanced materials requiring high-purity chiral components.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in regulatory environments.

Basic Information

Product Name	n-Tfa-L-Valine Methyl Ester
CAS No.	1463-21-4
Molecular Formula	C8H12F3NO3
Molecular Weight	227.18 g/mol
Synonyms	N-(Trifluoroacetyl)-L-valine methyl ester; Methyl N-trifluoroacetyl-L-valinate; L-Valine, N-[(trifluoroacetyl)-, methyl ester; Methyl (2S)-3-methyl-2-[(trifluoroacetyl)amino]butanoate; TFA-L-Val-OMe; N-TFA-L-Val-OMe; (S)-Methyl 3-methyl-2-(2,2,2-trifluoroacetamido)butanoate; Methyl N-(trifluoroacetyl)valinate
EINECS	215-967-5

Quality Control

Our n-Tfa-L-Valine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.