Description

Trimethyl Orthoacetate is a versatile orthoester compound, primarily valued as a key reagent and protecting group in organic synthesis. Its high reactivity makes it indispensable for the formation of acetals and as a precursor in the synthesis of heterocycles and complex pharmaceutical intermediates. This product is essential for research and production in the fine chemical, pharmaceutical, and agrochemical industries, where precise molecular construction is critical.

Application

• Pharmaceutical Synthesis: A crucial building block for the production of active pharmaceutical ingredients (APIs), particularly in the synthesis of nucleosides, antiviral agents, and other heterocyclic compounds.
• Agrochemical Manufacturing: Used as an intermediate in the synthesis of pesticides, herbicides, and plant growth regulators.
• Fine Chemical Production: Serves as a protecting group for carbonyls and a reagent in the synthesis of fragrances, flavors, and specialty dyes.
• Polymer Chemistry: Employed as a modifier or cross-linking agent in the development of specialty polymers and resins.
• Academic & Industrial R&D: A fundamental reagent for method development and exploratory synthesis in organic chemistry laboratories.

Basic Information

Product Name	Trimethyl Orthoacetate
CAS No.	1445-45-0
Molecular Formula	C5H12O3
Molecular Weight	120.15 g/mol
Synonyms	Methyl Orthoacetate; Trimethoxyethane; 1,1,1-Trimethoxyethane; Acetaldehyde Trimethyl Acetal; Orthoacetic Acid Trimethyl Ester; TMOA; Trimethylacetate (ortho)
EINECS	215-889-2

Quality Control

Our Trimethyl Orthoacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including gas chromatography (GC) for purity and identity confirmation, to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from heat and ignition sources. Due to its highly volatile and hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent moisture absorption and degradation. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.1%
Refractive Index (n20D)	1.384 - 1.388
Density (20°C)	0.94 - 0.97 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.