Description

(2R,5S)-4,4'Aα,5,5',6',7',8',8'A-Octahydro-2',5,5',5',8'Aβ-Pentamethylspiro[Furan-2(3H),1'(4'H)-Naphthalene]-5-Acetic Acid Methyl Ester is a high-purity, complex spirocyclic compound with significant synthetic utility. This advanced chiral intermediate is valued for its unique structural framework, which serves as a critical building block in the synthesis of complex organic molecules. It is primarily sought after by research institutions and pharmaceutical development companies engaged in the creation of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in complex natural product synthesis.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective chemical reactions to construct molecules with defined three-dimensional architecture.
• Organic Chemistry Research: Serves as a model compound or starting material in academic and industrial research exploring new synthetic methodologies and reaction pathways.
• Fragrance and Flavor Chemistry: Potential use as an intermediate in the synthesis of complex, high-value odorants and flavorants due to its intricate polycyclic structure.
• Agrochemical Development: Employed in the discovery phase for creating new, structurally complex active ingredients with potential pesticidal or herbicidal activity.
• Material Science Precursor: Can be investigated as a monomer or precursor for specialized polymers or advanced organic materials requiring specific stereochemistry.

Basic Information

Product Name	(2R,5S)-4,4'Aα,5,5',6',7',8',8'A-Octahydro-2',5,5',5',8'Aβ-Pentamethylspiro[Furan-2(3H),1'(4'H)-Naphthalene]-5-Acetic Acid Methyl Ester
CAS No.	1438-58-0
Molecular Formula	C22H34O3
Molecular Weight	346.51 g/mol
Synonyms	Methyl (2R,5S)-4,4'Aα,5,5',6',7',8',8'A-Octahydro-2',5,5',5',8'Aβ-pentamethylspiro[furan-2(3H),1'(4'H)-naphthalene]-5-acetate; Ambroxide Precursor; Spiro[4.5]decan-6-one derivative; (2R,5S)-Ambrox Methyl Ester Intermediate; 8α,12-Epoxy-13,14,15,16-tetranorlabdan-5β-ol acetate derivative; CAS 1438-58-0; Ambrox Methyl Ester (stereospecific)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, and chiral analysis to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and cGMP-grade requirements, with quality systems designed to meet the stringent needs of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound should be kept under an inert atmosphere if long-term storage is required to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.