Description

1,4-Dibromo-2-Fluorobenzene is a halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine atoms, which enables selective functionalization for creating complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and brominated aromatic cores for enhanced bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom often improves lipophilicity and target binding.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated organic electronic materials, contributing to the performance of displays and lighting.
• Cross-Coupling Reactions: The bromine atoms are excellent handles for palladium-catalyzed reactions like Suzuki, Heck, and Sonogashira couplings, enabling rapid diversification of chemical libraries.
• Fluorine Chemistry Research: A valuable reagent for studying the effects of fluorine substitution on aromatic systems and for developing new fluorination methodologies.
• Polymer Modification: Employed to introduce halogenated aromatic units into polymer backbones, altering physical properties such as thermal stability and refractive index.

Basic Information

Product Name	1,4-Dibromo-2-Fluorobenzene
CAS No.	1435-52-5
Molecular Formula	C6H3Br2F
Molecular Weight	253.89 g/mol
Synonyms	2-Fluoro-1,4-dibromobenzene; 1,4-Dibromo-2-fluorobenzene; 2-Fluorobenzene-1,4-dibromide; p-Dibromo-o-fluorobenzene; 1,4-Dibromo-2-fluoro-benzene; Benzene, 1,4-dibromo-2-fluoro-; NSC 403124
EINECS	Contact for details

Quality Control

Our 1,4-Dibromo-2-Fluorobenzene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to verify identity and quantify impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.