Description

α-Cyclobutyl-α-Hydroxybenzeneacetic Acid Methyl Ester is a specialized chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in the presence of both a cyclobutyl group and a benzylic hydroxyl moiety, which are key structural motifs for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in therapeutic areas targeting the central nervous system or metabolic diseases.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the cyclobutyl ring can contribute to unique biological activity and environmental profiles.
• Asymmetric Catalysis Research: Serves as a valuable substrate or ligand precursor in academic and industrial research focused on developing new stereoselective synthetic methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Material Science Precursor: Potential use as a monomer or building block for synthesizing novel polymers with specific thermal or mechanical properties.

Basic Information

Product Name	α-Cyclobutyl-α-Hydroxybenzeneacetic Acid Methyl Ester
CAS No.	1209-31-0
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.26 g/mol
Synonyms	Methyl 2-cyclobutyl-2-hydroxy-2-phenylacetate; Methyl α-cyclobutylmandelate; 2-Cyclobutyl-2-hydroxy-2-phenylacetic acid methyl ester; α-Hydroxy-α-cyclobutylbenzeneacetic acid methyl ester; (RS)-Methyl 2-cyclobutyl-2-hydroxy-2-phenylacetate; (±)-Methyl 2-cyclobutyl-2-hydroxy-2-phenylacetate; Mandelic acid, α-cyclobutyl-, methyl ester
EINECS	Contact for details

Quality Control

Our α-Cyclobutyl-α-Hydroxybenzeneacetic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 98.0%
Optical Purity (Chiral HPLC)	Contact for details
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.