Description

Z-Ala-Onp CAS NO 1168-87-2 is a high-purity, protected amino acid derivative, specifically the p-nitrophenyl ester of N-benzyloxycarbonyl-L-alanine. This compound serves as a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential addition of amino acids. It is essential for research and development laboratories, pharmaceutical intermediates manufacturers, and fine chemical producers focused on creating novel peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester, it is used for the efficient incorporation of the alanine residue into growing peptide chains under mild conditions.
• Solution-Phase Peptide Coupling: Employed in classical solution-phase methods for the synthesis of short peptide sequences and fragments.
• Pharmaceutical Intermediate: A key raw material in the production of therapeutic peptides, including hormone analogs and enzyme inhibitors.
• Bioconjugation and Labeling: Useful for attaching peptides or the alanine moiety to other molecules, surfaces, or probes for biochemical studies.
• Academic and Industrial R&D: Fundamental reagent for medicinal chemistry research, exploring structure-activity relationships (SAR) in drug discovery projects.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Z-Ala-Onp
CAS No.	1168-87-2
Molecular Formula	C17H16N2O6
Molecular Weight	344.32 g/mol
Synonyms	N-Cbz-L-alanine 4-nitrophenyl ester; N-Carbobenzoxy-L-alanine p-nitrophenyl ester; Z-L-Ala-ONp; (S)-2-(((Benzyloxy)carbonyl)amino)propanoic acid 4-nitrophenyl ester; Nα-Cbz-L-alanine p-nitrophenyl ester; Cbz-Ala-ONp; Benzyloxycarbonyl-L-alanine p-nitrophenyl ester; N-Benzyloxycarbonyl-L-alanine 4-nitrophenyl ester
EINECS	Contact for details

Quality Control

Our Z-Ala-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and optical rotation tests. Our quality commitment supports applications in GMP intermediate manufacturing and critical research where reliable purity is non-negotiable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Melting Point	118°C - 122°C
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.