Description

Diethyl 1,4-Dihydro-2,4,6-Trimethyl-3,5-Pyridinedicarboxylate is a high-purity Hantzsch ester derivative, a versatile intermediate and reagent critical for advanced organic synthesis. Its primary value lies in its role as a potent, non-toxic reducing agent and a key building block for constructing complex nitrogen-containing heterocycles. This compound is essential for research and production in the pharmaceutical, agrochemical, and fine chemical industries, particularly for scientists developing novel active ingredients and catalytic systems.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of calcium channel blockers (e.g., Nifedipine analogs) and other active pharmaceutical ingredients (APIs) containing dihydropyridine cores.
• Organic Reducing Agent: Used as a mild, non-metal-based reducing agent in various organic transformations, including radical dehalogenations and reductive aminations.
• Hantzsch Pyridine Synthesis: Serves as a key precursor and model compound in the classic Hantzsch reaction for producing symmetrical and asymmetrical dihydropyridines and pyridines.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides that utilize the dihydropyridine scaffold.
• Ligand & Catalyst Precursor: Utilized in coordination chemistry to develop novel ligands and catalysts for asymmetric synthesis and polymerization reactions.
• Fine Chemical & Dye Intermediate: Acts as an intermediate in the production of specialty chemicals, dyes, and photoinitiators.
• Academic & R&D: A fundamental reagent in university and industrial research laboratories for methodological development in synthetic organic chemistry.

Basic Information

Product Name	Diethyl 1,4-Dihydro-2,4,6-Trimethyl-3,5-Pyridinedicarboxylate
CAS No.	1150-55-6
Molecular Formula	C14H21NO4
Molecular Weight	267.32 g/mol
Synonyms	Hantzsch Ester; Diethyl Hantzsch Ester; Diethyl 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate; DEH; 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic Acid Diethyl Ester; 3,5-Pyridinedicarboxylic Acid, 1,4-Dihydro-2,4,6-trimethyl-, Diethyl Ester; Ethyl Hantzsch Ester; Nifedipine Intermediate
EINECS	214-548-8

Quality Control

Our Diethyl 1,4-Dihydro-2,4,6-Trimethyl-3,5-Pyridinedicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	155 - 160 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.