Description

Norephedrine, Sulfate CAS NO 1130-06-9 is the sulfate salt form of the sympathomimetic amine, phenylpropanolamine. This compound is a key chiral intermediate and active pharmaceutical ingredient (API) with significant commercial value in regulated synthesis. It is essential for manufacturers requiring a high-purity, reliable building block for pharmaceutical and fine chemical production. Target industries include pharmaceutical R&D, contract manufacturing organizations (CMOs), and producers of specialized chemical intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of decongestants, appetite suppressants, and other adrenergic agents.
• Chiral Building Block: Utilized in asymmetric synthesis to construct more complex molecules with defined stereochemistry.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Chemical Research: Used in academic and industrial research for studying sympathomimetic activity and developing new therapeutic compounds.
• Veterinary Pharmaceuticals: Employed in the formulation of specific veterinary medicinal products.

Basic Information

Product Name	Norephedrine, Sulfate
CAS No.	1130-06-9
Molecular Formula	C18H26N2O4S
Molecular Weight	366.48 g/mol
Synonyms	Phenylpropanolamine Sulfate; Norfenefrine Sulfate; (±)-Norephedrine Sulfate; dl-Norephedrine Sulfate; (RS)-Norephedrine Sulfate; 1-Phenyl-2-amino-1-propanol Sulfate; α-(1-Aminoethyl)benzyl alcohol sulfate
EINECS	214-462-9

Quality Control

Our Norephedrine Sulfate is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Specifications can be aligned with in-house pharmacopeial standards or custom client requirements to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.