Description

n-Trifluoroacetyl-L-Leucine Methyl Ester is a specialized chiral building block and protected amino acid derivative of significant value in advanced organic synthesis. Its core utility lies in the trifluoroacetyl (TFA) protecting group, which offers distinct advantages in peptide chemistry due to its stability under various conditions and its ease of removal. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: A key protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: Serves as a critical chiral building block in the research and production of peptide-based therapeutics and active pharmaceutical ingredients (APIs).
• Bioconjugation & Labeling: Used in the preparation of modified peptides for bioconjugation, probe development, and diagnostic applications.
• Chemical Biology Research: Employed in the study of enzyme mechanisms, protein-protein interactions, and the development of enzyme inhibitors.
• Process Development: Utilized in scaling up synthetic routes for peptide drugs, ensuring reproducibility and high yield.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists in universities and corporate R&D laboratories exploring new molecular entities.

Basic Information

Product Name	n-Trifluoroacetyl-L-Leucine Methyl Ester
CAS No.	1115-39-5
Molecular Formula	C9H14F3NO3
Molecular Weight	241.21 g/mol
Synonyms	L-Leucine, N-[(trifluoroacetyl)-, methyl ester; Methyl N-trifluoroacetyl-L-leucinate; N-(Trifluoroacetyl)-L-leucine methyl ester; TFA-L-Leucine-OMe; Trifluoroacetyl-L-leucine methyl ester; (S)-Methyl 2-(2,2,2-trifluoroacetamido)-4-methylpentanoate; Methyl (2S)-4-methyl-2-[(2,2,2-trifluoroacetyl)amino]pentanoate
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetyl-L-Leucine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and related substances is available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.