Description

1-Phenyl-1,3,8-Triazaspiro[4.5]Decan-4-One is a structurally unique spirocyclic heteroamine featuring three nitrogen atoms within a fused triaza-spirodecanone scaffold. This compound serves as a high-value synthetic intermediate in medicinal chemistry, particularly for the development of neuropharmacological agents and selective receptor modulators. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in novel CNS-active compound synthesis. The 1-Phenyl-1,3,8-Triazaspiro[4.5]Decan-4-One CAS NO 1021-25-6 is recognized for its molecular rigidity and hydrogen-bonding capacity—key attributes that enhance target selectivity and metabolic stability in lead optimization campaigns.

Application

• Key building block in the synthesis of serotonin (5-HT6) and dopamine D3 receptor antagonists
• Intermediate for spirocyclic piperazine derivatives used in antipsychotic and anti-anxiety drug candidates
• Core scaffold in structure–activity relationship (SAR) studies targeting G-protein-coupled receptors (GPCRs)
• Substrate for late-stage functionalization (e.g., N-alkylation, C–H activation) in parallel medicinal chemistry libraries
• Chiral resolution substrate for asymmetric synthesis of enantiopure spiroamines
• Reference standard in LC-MS/MS method development for neuroactive metabolite quantification

Basic Information

Product Name	1-Phenyl-1,3,8-Triazaspiro[4.5]Decan-4-One
CAS No.	1021-25-6
Molecular Formula	C13H15N3O
Molecular Weight	229.28 g/mol
Synonyms	1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one; 1-Phenylspiro[4.5]decan-4-one-1,3,8-triazine; NSC 127422; SPIRO-4-ONE-PHENYL; 1-Phenyl-4-oxo-1,3,8-triazaspiro[4.5]decane; 1-Phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride (salt form); 4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane; TSD-4-O
EINECS	213-967-1

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches of 1-Phenyl-1,3,8-Triazaspiro[4.5]Decan-4-One are verified per ACS-grade specifications, including identity confirmation (IR, 1H-NMR), assay purity (≥98.5% by HPLC), residual solvent limits (ICH Q3C), and heavy metal content (<10 ppm). Testing adheres to ISO/IEC 17025-accredited protocols, and full traceability is maintained from raw material sourcing through final packaging.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Keep away from strong oxidizing agents and moisture sources. For long-term stability, maintain under inert atmosphere (nitrogen or argon) due to potential sensitivity to oxidation and humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (1H-NMR)	Conforms to reference spectrum (DMSO-d6)
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	≤1.0% total impurities
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water (Karl Fischer)	≤0.5%
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.