Description

(-)3,4-Dihydroxynorephedrine is a chiral catecholamine derivative of significant interest in pharmaceutical and biochemical research. This compound serves as a key intermediate and reference standard in the synthesis and study of adrenergic agents and neurotransmitters. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, cardiovascular research, and drug discovery. The high-purity material is essential for ensuring accurate experimental results and reliable process development.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of more complex adrenergic drugs and neurological agents.
• Biochemical Research: Used as a reference standard and tool compound in studies of catecholamine metabolism, neurotransmission, and receptor binding assays.
• Neuroscience Studies: Applied in research models investigating Parkinson's disease, depression, and other disorders related to dopamine and norepinephrine pathways.
• Analytical Standard: Serves as a high-purity calibrant for analytical methods such as HPLC, LC-MS, and GC-MS in quality control laboratories.
• Metabolite Synthesis: Utilized in the preparation of drug metabolites for pharmacokinetic and toxicological profiling.
• Enzymology Studies: Acts as a substrate for enzymes like catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO).

Basic Information

Item	Detail
Product Name	(-)3,4-Dihydroxynorephedrine
CAS No.	138-61-4
Molecular Formula	C9H13NO3
Molecular Weight	183.20 g/mol
Synonyms	(-)-Norfenefrine; (1R,2S)-1-(3,4-Dihydroxyphenyl)-2-amino-1-propanol; (R)-(-)-α-(Aminomethyl)-3,4-dihydroxybenzyl alcohol; Levo-Nordefrin; (-)-α-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol; (-)-3,4-Dihydroxynoradrenaline; L-three-3,4-Dihydroxynorephedrine
EINECS	205-335-7

Quality Control

Our (-)3,4-Dihydroxynorephedrine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.