Description

2-Chloropyridine CAS NO 109-09-1 is a versatile halogenated heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its value lies in the reactivity of the chlorine atom, which enables efficient functionalization and the construction of complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of various active pharmaceutical ingredients (APIs), including antiviral and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Building block for creating herbicides, insecticides, and fungicides, leveraging its pyridine core for biological activity.
• Ligand and Catalyst Preparation: Used to synthesize bipyridine and other nitrogen-containing ligands for metal catalysis and coordination chemistry.
• Material Science: Intermediate in the production of functional polymers, liquid crystals, and electronic chemicals.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The chlorine atom is readily displaced by various nucleophiles (amines, alkoxides) to create diversely substituted pyridines.

Basic Information

Product Name	2-Chloropyridine
CAS No.	109-09-1
Molecular Formula	C5H4ClN
Molecular Weight	113.54 g/mol
Synonyms	2-Chloropyridine; α-Chloropyridine; o-Chloropyridine; 2-Pyridyl chloride; Pyridine, 2-chloro-; NSC 8775; 2-Cl-Py
EINECS	203-646-5

Quality Control

Our 2-Chloropyridine is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets precise customer specifications and industry standards. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Density (20°C)	1.190 - 1.210 g/mL
Refractive Index (n20/D)	1.530 - 1.534

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.