Description

(R)-(+)-1,2-Dithiolane-3-Pentanoic Acid is the biologically active enantiomer of α-lipoic acid, a vital organosulfur cofactor in mitochondrial energy metabolism. This high-purity chiral compound is essential for research and development in advanced pharmaceutical and nutraceutical formulations, where stereochemical integrity directly impacts biological efficacy. It is primarily sought by manufacturers and R&D laboratories in the pharmaceutical, dietary supplement, and advanced biochemical synthesis sectors.

Application

• Pharmaceutical Active Ingredient: Key chiral building block for synthesizing enantiopure therapeutics targeting metabolic disorders and neurological conditions.
• Dietary Supplement Formulation: Premium-grade raw material for high-end nutraceutical products emphasizing bioavailability and specific enantiomeric activity.
• Biochemical Research: Critical standard and reagent in studies of mitochondrial function, antioxidant mechanisms, and redox signaling pathways.
• Cosmeceutical Actives: Incorporated into advanced skincare formulations for its potent antioxidant and anti-aging properties.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of α-lipoic acid products.
• Enantioselective Synthesis: Serves as a chiral precursor or catalyst in sophisticated organic synthesis for complex molecules.

Basic Information

Product Name	(R)-(+)-1,2-Dithiolane-3-Pentanoic Acid
CAS No.	1200-22-2
Molecular Formula	C8H14O2S2
Molecular Weight	206.33 g/mol
Synonyms	(R)-(+)-α-Lipoic Acid; R-(+)-Lipoic Acid; (R)-5-(1,2-Dithiolan-3-yl)pentanoic Acid; (R)-Thioctic Acid; R-ALA; Dehydrolipoic Acid; 6,8-Thioctic Acid (R-enantiomer); (R)-1,2-Dithiolane-3-valeric Acid
EINECS	214-874-6

Quality Control

Our (R)-(+)-1,2-Dithiolane-3-Pentanoic Acid is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical and nutraceutical applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	46 - 49 °C
Specific Rotation [α]20/D	+ 115° to + 120° (c=1, benzene)
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.