Alkylating Antineoplastic Agents

Alkylating Antineoplastic Agents

Alkylating antineoplastic agents are cytotoxic APIs that form covalent bonds with DNA, leading to cross-linking, strand breaks, and inhibition of replication and transcription. This class includes nitrogen mustards, nitrosoureas, alkyl sulfonates, triazenes, and platinum-based drugs. They are effective against a wide range of hematologic malignancies and solid tumors such as breast cancer, ovarian cancer, sarcomas, and brain tumors. Their mechanism is cell cycle–nonspecific, making them particularly active against rapidly dividing cells. However, their strong cytotoxicity can result in bone marrow suppression, infertility, and secondary malignancies. Despite these risks, alkylating agents remain foundational drugs in many chemotherapeutic regimens due to their broad antitumor activity.

Pyruvic Acid Thiosemicarbazone-Platinum Complex CAS NO 91811-98-2

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CAS No.:91811-98-2

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N,n-Bis(2-Chloroethyl)-7-Methyl-2-Propyl-1,8-Naphthyridin-4-Amine CAS NO 91860-16-1

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CAS No.:91860-16-1

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n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-7-Chloro-Quino Lin-4-Amine CAS NO 91919-60-7

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CAS No.:91919-60-7

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n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-7-(Trifluorome Thyl)Quinolin-4-Amine CAS NO 91919-63-0

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CAS No.:91919-63-0

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n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-6-Methoxy-2-Me Thyl-Quinolin-4-Amine CAS NO 91919-67-4

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CAS No.:91919-67-4

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n-[[4-[Bis(2-Chloroethyl)Amino]Phenyl]Methylideneamino]-7-Ethoxy-2-Met Hyl-Quinolin-4-Amine CAS NO 91919-70-9

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CAS No.:91919-70-9

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Fotemustine CAS NO 92118-27-9

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CAS No.:92118-27-9

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Diammineascorbatoplatinum(Ii) CAS NO 92266-72-3

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CAS No.:92266-72-3

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