Polypeptides
Polypeptides
Polypeptide antibiotics are APIs composed of cyclic or linear peptide structures that disrupt bacterial cell membranes, leading to rapid bactericidal effects. Key members include polymyxins (colistin), bacitracin, and tyrothricin. They are active primarily against multidrug-resistant Gram-negative organisms by binding to lipopolysaccharides and altering membrane permeability. Due to nephrotoxicity and neurotoxicity concerns, systemic use is limited to severe infections such as carbapenem-resistant Acinetobacter or Pseudomonas. Topical and ophthalmic formulations are widely used for skin and eye infections. Polypeptides have regained importance in the era of antimicrobial resistance as last-resort therapies.
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