Description

(S)-TRIP, (11bS)-4-Hydroxy-2,6-bis[2,4,6-tris(1-methylethyl)phenyl]dinaphtho[2,1-d:1',2'-f]-1,3,2-dioxaphosphepin 4-oxide is a highly specialized, chiral monophosphoric acid derivative, widely recognized as a privileged organocatalyst and Brønsted acid catalyst. Its value lies in its ability to induce high enantioselectivity in a broad spectrum of asymmetric transformations, offering researchers and process chemists a powerful tool for constructing complex chiral molecules. This compound is essential for R&D and production in pharmaceuticals and fine chemicals, where precise stereochemical control is paramount.

Application

• Asymmetric Organocatalysis: As a chiral Brønsted acid catalyst for enantioselective reactions including Friedel-Crafts alkylations, transfer hydrogenations, and Mannich-type reactions.
• Pharmaceutical Intermediate Synthesis: For the stereoselective construction of key chiral building blocks and active pharmaceutical ingredients (APIs).
• Chiral Resolution & Analysis: Potential use as a chiral selector or auxiliary in analytical method development for separating enantiomers.
• Academic & Industrial R&D: A critical reagent for methodological development in synthetic organic chemistry and process optimization.
• Fine Chemical Production: Enabling the synthesis of enantiomerically pure agrochemicals, flavors, and fragrances.
• Ligand & Catalyst Design: Serving as a sophisticated precursor or core structure for developing new chiral ligands and catalytic systems.

Basic Information

Product Name	(S)-TRIP
CAS No.	874948-63-7
Molecular Formula	C68H79O4P
Molecular Weight	991.31 g/mol
Synonyms	(S)-3,3'-Bis(2,4,6-triisopropylphenyl)-1,1'-bi-2-naphthol cyclic monophosphate; (S)-TRIP Phosphoric Acid; (S)-TRIP PA; (11bS)-4-Hydroxy-2,6-bis(2,4,6-triisopropylphenyl)dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide; (S)-TRIP Catalyst; Chiral Phosphoric Acid (S)-TRIP; (S)-TRIP Monophosphate; (S)-TRIP Brønsted Acid Catalyst
EINECS	Contact for details

Quality Control

Our (S)-TRIP is produced under strict quality management protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral analysis to confirm enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and specific rotation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as argon or nitrogen for long-term storage to maintain optimal catalytic activity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.