Description

Dmt-2'o-Tbdms-Ra(Tac) Amidite 0.5G Ab is a high-purity, phosphoramidite monomer specifically designed for solid-phase oligonucleotide synthesis. This compound is critical for the automated production of DNA and RNA sequences, enabling precise control over the genetic building blocks. It is an essential raw material for research institutions, diagnostic developers, and pharmaceutical companies engaged in therapeutic oligonucleotide development, genetic research, and molecular diagnostics.

Application

• Solid-Phase Oligonucleotide Synthesis: As a key phosphoramidite building block in automated DNA/RNA synthesizers.
• Therapeutic Oligonucleotide Manufacturing: Production of antisense oligonucleotides, siRNA, and aptamers for drug development.
• Research-Grade Primer & Probe Synthesis: For PCR, qPCR, sequencing, and other molecular biology techniques.
• Diagnostic Reagent Production: Manufacturing of labeled probes for clinical diagnostics and bioassays.
• Synthetic Biology: Construction of artificial genes and genetic circuits.
• Antisense Technology: Research and development of gene silencing applications.

Basic Information

Product Name	Dmt-2'o-Tbdms-Ra(Tac) Amidite 0.5G Ab
CAS No.	149989-64-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-(phenoxyacetyl)adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-TBDMS-N6-Pac-Adenosine Phosphoramidite; 5'-DMT-2'-O-TBDMS-N-Pac-Adenosine-3'-CE Phosphoramidite; N6-Phenoxyacetyl-2'-O-TBDMS-5'-O-DMT-Adenosine-3'-phosphoramidite; Adenosine, N6-(phenoxyacetyl)-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; Amidite for RNA (A) synthesis; RNA Phosphoramidite (A derivative).
EINECS	Contact for details

Quality Control

Our Dmt-2'o-Tbdms-Ra(Tac) Amidite is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, which is paramount for successful oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and 31P NMR, to confirm identity, purity, and reactivity. Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.