Description

Lawesson's Reagent is a versatile and highly effective sulfur-transfer reagent widely used in organic synthesis. Its primary value lies in its ability to efficiently convert carbonyl groups into their corresponding thiocarbonyl analogs, a critical transformation for synthesizing various sulfur-containing heterocycles and building blocks. This makes it an indispensable tool for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries.

Application

• Thionation of Carbonyls: Key reaction for converting ketones, amides, lactams, and esters into their thio-analogs (thioketones, thioamides, thiolactams, thioesters).
• Heterocyclic Synthesis: Crucial for constructing sulfur-containing heterocycles like thiophenes, thiazoles, and dithioles, which are common scaffolds in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Production: Used in the synthesis of drug candidates and final drug substances, particularly those requiring thioamide or thiourea functional groups.
• Agrochemical Development: Applied in creating novel herbicides, fungicides, and insecticides that incorporate sulfur-based bioactive moieties.
• Material Science Research: Facilitates the synthesis of organic semiconductors, ligands for metal complexes, and novel polymers with unique electronic properties.
• Academic & Process Chemistry: A staple reagent in research laboratories for methodological development and scaling up synthetic routes.

Basic Information

Product Name	Lawesson's Reagent
CAS No.	19172-47-5
Molecular Formula	C14H14O2P2S4
Molecular Weight	404.46 g/mol
Synonyms	2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide; LR; 2,4-Bis(p-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide; Björkman's Reagent; Dithiophosphoric acid O,O-bis(4-methoxyphenyl) ester dimer
EINECS	242-848-3

Quality Control

Our Lawesson's Reagent is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance. Each lot is analyzed to confirm identity, purity, and reactivity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and efficacy.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	228 - 232 °C
Loss on Drying	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.