Description

1,3-Benzoxaphosphole, 3-(1,1-Dimethylethyl)-2,3-dihydro-4-(2-methoxyphenyl)-2-(1-methylethyl)-, (2S,3S)- is a chiral, organophosphorus heterocyclic compound of significant interest in advanced synthetic chemistry. Its value lies in its potential as a key chiral building block or ligand for asymmetric catalysis and pharmaceutical intermediate synthesis. This high-purity specialty chemical is primarily needed by research institutions and pharmaceutical R&D departments focused on developing novel active ingredients and catalytic processes. The compound, identified by CAS No. 2565792-33-6, represents a sophisticated tool for chemists exploring new reaction pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) or oncology targets.
• Asymmetric Catalysis Ligand: Used in the development of novel chiral catalysts for enantioselective synthesis, where its rigid benzoxaphosphole scaffold can induce high stereoselectivity.
• Organic Synthesis Building Block: Employed in academic and industrial research for constructing complex, phosphorus-containing heterocycles with defined stereochemistry.
• Material Science Research: Investigated for potential applications in creating chiral functional materials or as a component in advanced polymer systems.
• Agrochemical Intermediate: Potential use in the research and development of novel, chiral active ingredients for crop protection.

Basic Information

Product Name	1,3-Benzoxaphosphole, 3-(1,1-Dimethylethyl)-2,3-dihydro-4-(2-methoxyphenyl)-2-(1-methylethyl)-, (2S,3S)-
CAS No.	2565792-33-6
Molecular Formula	C21H27O2P
Molecular Weight	342.41 g/mol
Synonyms	(2S,3S)-3-(tert-Butyl)-4-(2-methoxyphenyl)-2-isopropyl-2,3-dihydro-1,3-benzoxaphosphole; (2S,3S)-3-tert-Butyl-4-(2-methoxyphenyl)-2-isopropyl-2,3-dihydrobenzo[d][1,3]oxaphosphole; (2S,3S)-2-Isopropyl-3-tert-butyl-4-(o-methoxyphenyl)-2,3-dihydro-1,3-benzoxaphosphole; Chiral Benzoxaphosphole Derivative; tert-Butyl Isopropyl Benzoxaphosphole; (2S,3S)-Dihydrobenzoxaphosphole; Organophosphorus Heterocycle
EINECS	Contact for details

Quality Control

This high-value chiral compound is produced under strict quality control protocols to ensure batch-to-batch consistency and enantiomeric purity. Our standard offering meets research-grade specifications, with HPLC purity typically ≥95% and enantiomeric excess (ee) verified by chiral analytical methods. A comprehensive Certificate of Analysis (COA) is provided with each batch, detailing identity, purity, chiral purity, and impurity profile. We adhere to cGMP principles where applicable for synthesis and handling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; therefore, containers should be kept sealed under an inert atmosphere when not in use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.