Description

5-[2-[[4-(7,7-dimethyl-9-oxo-8-oxa-10-azabicyclo[4.4.0]deca-1,3,5-trien-10-yl)-2-methyl-butan-2-yl]amino]-1-hydroxy-ethyl]-2-hydroxy-N-methyl-benzamide, methanesulfonic acid is a high-purity, non-racemic pharmaceutical intermediate and active ingredient. This compound is critical for its role in the synthesis of advanced therapeutic agents, particularly in the cardiovascular and respiratory domains. It is essential for pharmaceutical R&D laboratories, process development chemists, and manufacturers requiring a reliable supply of a complex, chiral building block for API production.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral intermediate in the production of specific β-adrenergic receptor antagonists.
• Pharmaceutical Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new drug candidates.
• Process Chemistry & Scale-Up: Serves as a critical starting material or intermediate for optimizing synthetic routes under GMP conditions.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical manufacturing.
• Cardiovascular Drug Manufacturing: Integral to the commercial synthesis of medications targeting hypertension and related conditions.
• Contract Manufacturing Organizations (CMOs): Supplied to CMOs for the production of finished dosage forms for global markets.

Basic Information

Product Name	5-[2-[[4-(7,7-dimethyl-9-oxo-8-oxa-10-azabicyclo[4.4.0]deca-1,3,5-trien-10-yl)-2-methyl-butan-2-yl]amino]-1-hydroxy-ethyl]-2-hydroxy-N-methyl-benzamide, methanesulfonic acid
CAS No.	81695-89-8
Molecular Formula	C30H41N3O7 • CH4O3S
Molecular Weight	Contact for details
Synonyms	Carvedilol Mesylate; Carvedilol Methanesulfonate; (RS)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol methanesulfonate; (±)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol methanesulfonate; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol methanesulfonate; BM 14190 mesylate; SKF 105517 mesylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided with each batch, detailing key parameters such as chiral purity, chemical purity, and residual solvents. We support compliance with ICH guidelines and can tailor specifications to meet specific GMP or customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.