Description

Glepaglutide CAS NO 914009-86-2 is a synthetic, long-acting glucagon-like peptide-2 (GLP-2) analog designed for therapeutic applications. This compound is engineered to offer enhanced stability and prolonged biological activity compared to native GLP-2, making it a critical component in advanced pharmaceutical development. It is primarily utilized by research institutions and pharmaceutical companies focused on developing treatments for gastrointestinal disorders, including short bowel syndrome (SBS).

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable formulations for the treatment of short bowel syndrome (SBS).
• Clinical Research & Development: Serves as a key investigational new drug (IND) for preclinical and clinical trials targeting intestinal failure and malabsorption.
• Biopharmaceutical Synthesis: Used in the development and scale-up of peptide-based therapeutics requiring long-acting GLP-2 receptor agonism.
• Metabolic Disorder Research: A vital tool in academic and industrial research studying GLP-2 pathways, intestinal adaptation, and nutrient absorption.
• Formulation Development: Employed in the creation of stable, sustained-release drug delivery systems, such as depot injections.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	Glepaglutide
CAS No.	914009-86-2
Molecular Formula	C172H265N47O55
Molecular Weight	3759.2 g/mol
Synonyms	ZP1848; Glepaglutide acetate; GLP-2 analog ZP1848; Teduglutide analog; Long-acting GLP-2 peptide; Glepaglutide (ZP1848); GLP-2 (1-33), human, Lys30(Nε-(γ-Glu(Nα-hexadecanoyl)))-; UNII-9M3H6A8U2F
EINECS	Contact for details

Quality Control

Our Glepaglutide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, peptide mapping, and mass spectrometry for identity confirmation, to ensure it meets stringent pharmaceutical-grade specifications. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings for clinical or commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Peptide Content (Amino Acid Analysis)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	5.0% - 15.0%
Bacterial Endotoxins	< 10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.