Description

Aviptadil CAS NO 40077-57-4 is a synthetic vasoactive intestinal peptide (VIP) analogue, a 28-amino acid peptide with significant biological activity. It is primarily valued for its potent bronchodilatory, anti-inflammatory, and immunomodulatory properties, making it a critical compound for advanced research and development. This peptide is essential for pharmaceutical researchers and manufacturers focused on developing novel therapeutics for respiratory conditions, inflammatory diseases, and neurological disorders.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of investigational drugs targeting pulmonary arterial hypertension (PAH) and acute respiratory distress syndrome (ARDS).
• Biomedical Research: Used as a reference standard and tool compound in preclinical studies to investigate VIP receptor (VPAC1/VPAC2) signaling pathways and their role in inflammation and smooth muscle relaxation.
• Therapeutic Development: Serves as a key intermediate in the development of peptide-based therapies for conditions like septic shock, Crohn's disease, and autoimmune disorders.
• Clinical Research: Employed in the manufacture of clinical trial materials for evaluating new treatment protocols for lung-related and neurological conditions.
• Diagnostic Agent Development: Potential use in developing diagnostic tools for diseases involving VIP receptor dysfunction.

Basic Information

Product Name	Aviptadil
CAS No.	40077-57-4
Molecular Formula	C₁₄₇H₂₃₈N₄₄O₄₂S
Molecular Weight	3325.8 g/mol
Synonyms	Vasoactive Intestinal Peptide (VIP), human, porcine, rat; VIP (1-28), human; PHI-27; Peptide Histidine Isoleucine; Aviptadil acetate; RLF-100; Vasoactive Intestinal Contractor; PHM-27; Peptide Histidine Methionine.
EINECS	Contact for details

Quality Control

Our Aviptadil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry for confirmation, and tests for residual solvents and endotoxins. We provide full traceability and Certificates of Analysis (COA) that detail all specifications. Production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere. Keep containers sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	5.0% - 12.0%
Peptide Content (Amino Acid Analysis)	≥ 80.0%
Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.