Description

Ziconotide Acetate is a synthetic, non-opioid analgesic peptide derived from the venom of the marine cone snail *Conus magus*. It is a highly selective N-type voltage-gated calcium channel blocker, offering a powerful mechanism of action for managing severe chronic pain. This compound is of critical importance for pharmaceutical research and development, particularly in the formulation of intrathecal therapies for patients with intractable pain who are refractory to systemic analgesics. Its unique neuroactive properties make it a valuable tool for neuroscientists and drug developers targeting novel pain management pathways.

Application

• Intrathecal Analgesia: Primary active pharmaceutical ingredient (API) for the formulation of non-opioid, intrathecal infusion solutions for severe chronic pain management.
• Neuroscience Research: A critical research tool for studying N-type calcium channel function, synaptic transmission, and neuropathic pain mechanisms in vitro and in vivo.
• Pharmaceutical Development: Used in the R&D of next-generation peptide-based analgesics and targeted drug delivery systems.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• Preclinical Studies: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies supporting regulatory filings for new drug applications.

Basic Information

Product Name	Ziconotide Acetate
CAS No.	914454-03-8
Molecular Formula	C₁₀₂H₁₇₂N₃₆O₃₂S₂ • xC₂H₄O₂
Molecular Weight	2639.1 g/mol (free base)
Synonyms	SNX-111; CI 1009; ω-Conotoxin MVIIA acetate; Ziconotide acetate salt; Prialt (brand name) acetate; Synthetic ω-conotoxin MVIIA acetate; N-type calcium channel blocker SNX-111 acetate
EINECS	Contact for details

Quality Control

Our Ziconotide Acetate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and peptide content, mass spectrometry for identity confirmation, and stringent tests for related substances, residual solvents, and endotoxins. We provide full traceability and Certificates of Analysis (COA) that detail compliance with in-house specifications developed for research and pharmaceutical use. Our quality commitment ensures batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Total Peptide Content)
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 8.0%
Acetate Content (IC)	3.0 - 8.0 mol/mol
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.