Description

(Z)-2-Methyl-2-butenoic acid [(3aR,4S,5R,6S,8S,10R,11S,11aR)-dodecahydro-5,10-dihydroxy-6,10-dimethyl-3-methylene-11-[(R)-2-methyl-1-oxobutoxy]-2-oxo-5,8-epoxycyclodeca[b]furan-4-yl] ester is a high-purity, structurally complex chemical intermediate of significant interest in advanced organic synthesis. Its intricate molecular architecture, featuring multiple chiral centers and functional groups, makes it a critical building block for the development of novel compounds with specific biological activities. This product is essential for research and development laboratories in the pharmaceutical and agrochemical sectors, where precise stereochemistry is paramount for creating targeted active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of complex drug candidates, particularly for antibiotics, anti-inflammatory agents, and other specialized therapeutics.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where its unique structure can contribute to specific modes of action.
• Advanced Organic Synthesis: Acts as a versatile scaffold for constructing complex natural product analogs and other structurally demanding molecules in academic and industrial R&D.
• Chiral Catalyst & Ligand Development: Provides a foundation for creating novel asymmetric catalysts and ligands used in enantioselective synthesis.
• Biochemical Probe Synthesis: Utilized in medicinal chemistry to create labeled compounds or probes for studying biological pathways and target engagement.

Basic Information

Product Name	(Z)-2-Methyl-2-butenoic acid [(3aR,4S,5R,6S,8S,10R,11S,11aR)-dodecahydro-5,10-dihydroxy-6,10-dimethyl-3-methylene-11-[(R)-2-methyl-1-oxobutoxy]-2-oxo-5,8-epoxycyclodeca[b]furan-4-yl] ester
CAS No.	75102-66-8
Molecular Formula	C26H38O9
Molecular Weight	494.58 g/mol
Synonyms	2-Methyl-2-butenoic acid 11-[(1R)-2-methyl-1-oxobutoxy]-4,5,6,7,8,9,10,11,11a,12-decahydro-5,10-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-5,8-epoxycyclodeca[b]furan-4-yl ester, (3aR,4S,5R,6S,8S,10R,11S,11aR)-rel-; 2-Butenoic acid, 2-methyl-, (3aR,4S,5R,6S,8S,10R,11S,11aR)-dodecahydro-5,10-dihydroxy-6,10-dimethyl-3-methylene-2-oxo-11-[(1R)-2-methyl-1-oxobutoxy]-5,8-epoxycyclodeca[b]furan-4-yl ester, (2Z)-; A derivative of Picrotoxinin; Tiglic acid ester of a picrotoxane derivative.
EINECS	Contact for details

Quality Control

Our (Z)-2-Methyl-2-butenoic acid ester is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to moisture and prolonged exposure to elevated temperatures.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.