Description

Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI) is a sophisticated, high-purity chemical intermediate designed for advanced synthesis. Its complex structure is critical for the precise construction of nucleoside analogs and other biologically active molecules. This compound is essential for research and development in the pharmaceutical and biotechnology sectors, particularly in oligonucleotide synthesis and medicinal chemistry.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of modified DNA and RNA sequences.
• Pharmaceutical R&D: Serves as a critical building block in the development of novel therapeutic agents, including antisense oligonucleotides and siRNA.
• Probe Development: Used in the creation of labeled nucleic acid probes for diagnostic and genomic research applications.
• Medicinal Chemistry: Enables the introduction of specific heterocyclic and protecting group functionalities into target molecules.
• Process Development: Employed in scaling up the production of nucleotide-based active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes studying nucleic acid chemistry and biology.

Basic Information

Product Name	Phosphoramidous acid, bis(1-methylethyl)-, (1S)-1-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl 2-cyanoethyl ester(9CI)
CAS No.	548430-99-5
Molecular Formula	C49H55N4O7PS
Molecular Weight	883.03 g/mol
Synonyms	1-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-(7,9-dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl)propyl diisopropylphosphoramidite 2-cyanoethyl ester; DMT-protected Pyrido[3',2':4,5]thieno[3,2-d]pyrimidinone Phosphoramidite; Nucleoside Phosphoramidite Intermediate; 7,9-Dimethyl-4-oxopyrido[3',2':4,5]thieno[3,2-d]pyrimidin-3(4H)-yl Propyl DMT Phosphoramidite; Custom Phosphoramidite Monomer; 548430-99-5
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality control protocols in facilities that adhere to cGMP (current Good Manufacturing Practice) standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized, requiring careful handling to maintain stability and performance. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.