Description

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, 2-[(4-nitrophenyl)methyl] ester, (4R,5S,6S)- is a sophisticated, high-purity chemical intermediate with a complex stereochemistry that is critical for advanced pharmaceutical synthesis. This compound serves as a key building block in the development of novel β-lactamase inhibitors and other targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of next-generation antibiotics and specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of advanced β-lactamase inhibitor compounds.
• Antibiotic Research & Development: Used as a core scaffold for developing new classes of antibiotics to combat drug-resistant bacteria.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex molecules with specific stereochemical configurations.
• API (Active Pharmaceutical Ingredient) Manufacturing: Employed in the production scale-up of targeted therapeutic agents.
• Biochemical Research: Utilized in studies exploring enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Process Chemistry Development: Key material for optimizing synthetic routes and developing efficient manufacturing processes.

Basic Information

Product Name	1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, 2-[(4-nitrophenyl)methyl] ester, (4R,5S,6S)-
CAS No.	503607-50-9
Molecular Formula	C30H30N4O8S
Molecular Weight	606.65 g/mol
Synonyms	(4R,5S,6S)-2-[(4-Nitrophenyl)methyl] 3-[[(3S,5S)-5-[[(3-Carboxyphenyl)carbamoyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate; β-lactamase inhibitor intermediate; (4R,5S,6S)-Avibactam p-nitrobenzyl ester derivative; PNB ester of a β-lactamase inhibitor precursor; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid PNB ester; Compound 503607-50-9
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. The material is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing all relevant specifications are provided with each shipment. We support compliance with cGMP standards for pharmaceutical applications, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.