Description

(2S,5R)-7-Oxo-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Sodium Salt is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound is a crucial building block in the synthesis of carbapenem antibiotics, a vital class of broad-spectrum β-lactam antimicrobials. It is essential for manufacturers in the pharmaceutical and fine chemical industries engaged in the research, development, and production of next-generation antibacterial agents.

Application

• Key Intermediate for Carbapenem Antibiotics: Serves as a core chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) like meropenem, ertapenem, and other carbapenem-class drugs.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and structural modification of novel β-lactam compounds with enhanced efficacy and resistance profiles.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct complex, biologically active molecules requiring the 7-oxo-1-azabicyclo[3.2.0]heptane skeleton.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the cGMP production of antibiotic drug substances and finished dosage forms.
• Academic & Institutional Research: Utilized in biochemical and pharmacological studies investigating bacterial cell wall synthesis and inhibition mechanisms.

Basic Information

Item	Details
Product Name	(2S,5R)-7-Oxo-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Sodium Salt
CAS No.	117858-73-8
Molecular Formula	C7H8NNaO3
Molecular Weight	177.14 g/mol
Synonyms	(2S,5R)-7-Oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid sodium salt; Sodium (2S,5R)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R)-7-Oxo-1-azabicyclo[3.2.0]heptane-2-carboxylate sodium salt; Meropenem intermediate; Carbapenem nucleus sodium salt; 1-Azabicyclo[3.2.0]heptane-2-carboxylic acid, 7-oxo-, sodium salt, (2S,5R)-; 117858-73-8
EINECS	Contact for details

Quality Control

Our (2S,5R)-7-Oxo-1-Azabicyclo[3.2.0]Heptane-2-Carboxylic Acid Sodium Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical synthesis. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and related substances are provided and can be tailored to meet specific customer or regulatory (e.g., ICH guidelines) specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (2S,5R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 1.5%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.