Description

Meropenem Trihydrate CAS NO 119478-56-7 is a broad-spectrum, β-lactam carbapenem antibiotic in its trihydrate salt form. This compound is critically important for its potent bactericidal activity against a wide range of Gram-positive and Gram-negative pathogens, including multi-drug resistant strains. It is an essential active pharmaceutical ingredient (API) primarily required by pharmaceutical manufacturers for the formulation of injectable antibiotic products used in hospital and clinical settings to treat severe infections.

Application

• Pharmaceutical API: Primary use as the active ingredient in sterile injectable formulations for intravenous or intramuscular administration.
• Treatment of Complicated Infections: Formulated for treating complicated intra-abdominal infections (cIAI), complicated skin and skin structure infections (cSSSI), and bacterial meningitis.
• Hospital-Acquired Pneumonia (HAP) & Ventilator-Associated Pneumonia (VAP): A key therapeutic agent in managing serious lower respiratory tract infections in hospitalized patients.
• Empirical Therapy for Febrile Neutropenia: Used in immunocompromised patients, such as those undergoing chemotherapy, where broad-spectrum coverage is crucial.
• Research & Development: Serves as a reference standard and starting material in pharmaceutical R&D for new antibiotic formulations and combination therapies.
• Veterinary Pharmaceuticals: Potential application in developing high-value antibiotic treatments for serious bacterial infections in animals.

Basic Information

Item	Detail
Product Name	Meropenem Trihydrate
CAS No.	119478-56-7
Molecular Formula	C17H25N3O5S · 3H2O
Molecular Weight	437.51 g/mol (as trihydrate)
Synonyms	Meropenem Trihydrate; (4R,5S,6S)-3-[[(3S,5S)-5-(Dimethylcarbamoyl)-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid Trihydrate; SM-7338 Trihydrate; ICI-194660 Trihydrate; Merrem; Meronem; Optinem; Carbapenem Antibiotic Trihydrate
EINECS	Contact for details

Quality Control

Our Meropenem Trihydrate is manufactured and tested under strict quality management systems. It is produced to meet high-purity standards suitable for pharmaceutical applications, with potential alignment to pharmacopeial monographs such as USP, EP, and JP. Each batch undergoes comprehensive analytical testing, including assay, impurity profiling, and microbiological examination. A Certificate of Analysis (COA) detailing all test results is provided to ensure full traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as specified. This material is hygroscopic (moisture-sensitive) and must be kept under conditions that minimize exposure to atmospheric humidity to prevent degradation. For long-term stability, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to slightly yellow crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC, on anhydrous basis)	98.0% - 102.0%
Water Content (KF)	11.0% - 13.0%
pH (1% solution)	4.0 - 6.0
Specific Optical Rotation	Contact for details
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Bacterial Endotoxins	< 0.17 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.