Description

(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid is a high-purity, complex triterpenoid glycoside of significant interest in advanced research and development. This compound matters as a critical reference standard and potential intermediate for investigating bioactive natural products. It is primarily needed by pharmaceutical R&D teams, nutraceutical formulators, and academic researchers focused on saponin chemistry and natural product synthesis.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel therapeutic agents, particularly those targeting metabolic or inflammatory pathways.
• Nutraceutical and Cosmetic Ingredient: Used in the formulation of high-end dietary supplements and skincare products for its potential bioactive properties derived from its saponin structure.
• Analytical Chemistry: Employed as a certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and other analytical techniques.
• Academic and Industrial Research: A vital tool for studying the structure-activity relationships (SAR) of complex glycosides and triterpenoids in biochemistry and medicinal chemistry.
• Process Chemistry Development: Acts as a benchmark compound for scaling up the synthesis of related natural product derivatives under Good Manufacturing Practice (GMP) conditions.

Basic Information

Item	Details
Product Name	(2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyl-oxan-2-yl]oxy-oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
CAS No.	55319-36-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Asiaticoside; Madecassoside; (2S,3S,4S,5R,6R)-6-(((3S,4S,4aR,6aR,6bS,8aR,9S,12aR,14aS,14bR)-9-Hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl)oxy)-5-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5S,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxytetrahydro-2H-pyran-2-carboxylic acid; Centelloside; Thankuniside; Triterpenoid saponin from Centella asiatica.
EINECS	Contact for details

Quality Control

Our Madecassoside (Asiaticoside) is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet stringent specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and safety parameters. We support compliance with GMP, ICH Q7, and other relevant pharmaceutical guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.