Description

Helleborein (CAS No. 1399-70-8) is a steroidal saponin of significant interest in advanced research and development. This compound matters for its potential as a key intermediate and active principle in the synthesis of specialized pharmaceutical agents and high-value biochemicals. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and fine chemical producers focused on cardiac glycoside analogs, natural product derivatives, and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical starting material or precursor in the synthesis of specialized steroidal drugs and cardiac-active compounds.
• Biochemical Research: Used as a reference standard and active agent in pharmacological studies, particularly those investigating mechanisms related to cardiac function and Na+/K+-ATPase inhibition.
• Natural Product Extraction & Standardization: A key marker compound for the quality control and standardization of extracts derived from Helleborus species and other botanical sources.
• Fine Chemical Synthesis: Employed in the development of novel chemical entities (NCEs) and complex molecular architectures within medicinal chemistry programs.
• Reference Material: Supplied as a high-purity compound for use in analytical testing, method development, and calibration in quality control laboratories.

Basic Information

Product Name	Helleborein
CAS No.	1399-70-8
Molecular Formula	C37H56O18
Molecular Weight	788.83 g/mol
Synonyms	Hellebrin; Corelborin; Helleborein; (3β,5β)-3-[(2,6-Dideoxy-4-O-β-D-glucopyranosyl-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-19-oxocard-20(22)-enolide; Hellebrigenin 3-O-β-D-glucopyranosyl-(1→4)-β-D-digitalopyranoside
EINECS	Contact for details

Quality Control

Our Helleborein is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay determination and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, related substances, and residual solvents as applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.