Description

Actinomycin E1 CAS NO 1402-41-1 is a potent chromopeptide antibiotic belonging to the actinomycin family, known for its characteristic phenoxazone chromophore. This compound is of significant interest due to its ability to intercalate into DNA, inhibiting transcription and making it a valuable tool in biochemical research. It is primarily utilized by research institutions and pharmaceutical developers in oncology and molecular biology studies to investigate mechanisms of action and develop novel therapeutic strategies.

Application

• Biochemical Research: Used as a specific inhibitor of RNA polymerase to study transcription mechanisms and gene expression.
• Oncology Research: Employed in in vitro and in vivo studies to investigate its cytotoxic effects and potential as a chemotherapeutic agent or a model compound.
• Antibiotic Mechanism Studies: Serves as a reference standard in microbiology to explore the action of DNA-binding antibiotics.
• Pharmaceutical Development: Acts as a key intermediate or reference material in the R&D of novel anti-cancer therapeutics.
• Cell Biology: Utilized to induce apoptosis in cell culture models for studying programmed cell death pathways.

Basic Information

Product Name	Actinomycin E1
CAS No.	1402-41-1
Molecular Formula	C62H86N12O16
Molecular Weight	1279.44 g/mol
Synonyms	Actinomycin E1; Actinomycin C1; Actinomycin IV; Actinomycin AIV; Actinomycin C; Sanamycin; Meractinomycin; Dactinomycin (Note: Dactinomycin typically refers to Actinomycin D, but is a common related search term)
EINECS	Contact for details

Quality Control

Our Actinomycin E1 is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 1.0%
Biological Activity	Assessed via in vitro assay (Contact for details)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.