Description

(4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid is a sophisticated carbapenem derivative, representing a key advanced intermediate in modern pharmaceutical synthesis. Its complex stereochemistry and functional groups make it a critical building block for developing potent β-lactam antibiotics. This high-purity compound is essential for research and manufacturing organizations focused on next-generation anti-infective therapies.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of novel carbapenem-class antibiotics.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for developing new antibacterial agents targeting resistant pathogens.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize antibiotic efficacy and pharmacokinetic profiles.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for complex β-lactam molecules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in antibiotic manufacturing.
• Biochemical Research: Utilized in studies investigating bacterial cell wall synthesis and the mechanisms of β-lactamase inhibition.

Basic Information

Product Name	(4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
CAS No.	426253-04-5
Molecular Formula	C19H23N3O4S2
Molecular Weight	421.53 g/mol
Synonyms	Carbapenem Intermediate; (4R,5S,6S)-3-[(4-((5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl)-2-thiazolyl)thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid; 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivative; β-lactam antibiotic intermediate; Thiazolylpyrrole carbapenem; CAS 426253-04-5
EINECS	Contact for details

Quality Control

Our (4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and stereochemical integrity, meeting the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The container should be kept in a dry, well-ventilated area. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.