Description

(4R,5S,6S)-3-[[(3S,5S)-5-[[[3-[[(1R,2S)-2-Carboxy-2-[(2S,3R)-5-carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)aMino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-3-Methyl-2H-pyrrol-2-yl]-1-Methylethoxy]carbonyl]phenyl]aMino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid is a complex, high-purity carbapenem derivative designed for advanced pharmaceutical research and development. This compound is critical for investigating novel β-lactamase inhibitors and developing next-generation antibiotics to combat resistant bacterial strains. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) focused on anti-infective drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor or building block in the development of novel carbapenem-class antibiotics.
• β-Lactamase Inhibitor Research: Used in biochemical and microbiological assays to study and develop potent inhibitors against serine β-lactamases.
• Mechanism of Action Studies: Employed in research to understand the binding affinity and interaction with penicillin-binding proteins (PBPs).
• Structure-Activity Relationship (SAR) Analysis: A critical compound for medicinal chemists to modify and optimize the carbapenem core for enhanced efficacy and spectrum.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation of related pharmaceutical products.
• Preclinical Drug Development: Integral to in vitro and in vivo studies during the early stages of developing new antibacterial agents.

Basic Information

Item	Details
Product Name	(4R,5S,6S)-3-[[(3S,5S)-5-[[[3-[[(1R,2S)-2-Carboxy-2-[(2S,3R)-5-carboxy-4-[[(3S,5S)-5-[[(3-carboxyphenyl)aMino]carbonyl]-3-pyrrolidinyl]thio]-3,4-dihydro-3-Methyl-2H-pyrrol-2-yl]-1-Methylethoxy]carbonyl]phenyl]aMino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-Methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic Acid
CAS No.	402955-38-8
Molecular Formula	C44H51N7O14S2
Molecular Weight	966.04 g/mol
Synonyms	Carbapenem derivative 402955-38-8; (4R,5S,6S)-3-[(3S,5S)-5-({3-[(1R,2S)-2-Carboxy-2-[(2S,3R)-5-carboxy-4-[(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]-3-pyrrolidinyl]sulfanyl]-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]-1-methylethoxy]carbonyl}phenyl)carbamoyl]-3-pyrrolidinyl]sulfanyl]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid; Advanced β-lactamase inhibitor intermediate; Complex carbapenem analog; Pharmaceutical research compound 402955-38-8
EINECS	Contact for details

Quality Control

This high-value pharmaceutical intermediate is produced under strict quality management systems. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from tests including HPLC purity, chiral purity, water content (KF), and residual solvents. Our quality protocols are designed to support cGMP and ICH guidelines for pharmaceutical development, ensuring the material is suitable for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.