Description

1-[2-[2-(Dimethylamino)-3-phenylpropanoylamino]-3-methylpentanoyl]-2,3,3a,13,14,15a-hexahydro-13-(1-methylpropyl)-5,8-ethenopyrrolo[3,2-b][1,5,8]oxadiazacyclotetradecine-12,15(1H,11H)-dione is a complex, high-purity macrocyclic compound of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture makes it a valuable intermediate or reference standard for the synthesis of novel therapeutic agents, particularly in oncology and targeted drug delivery. This product is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in cutting-edge medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), especially for novel cancer therapies.
• Medicinal Chemistry Research: Used as a key scaffold or precursor in drug discovery programs to explore new structure-activity relationships and develop targeted molecules.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry Development: Employed in optimizing synthetic routes, scaling up production, and ensuring reproducibility for advanced pharmaceutical compounds.
• Bioconjugation Studies: Potential use in developing antibody-drug conjugates (ADCs) or other targeted biopharmaceuticals due to its functionalizable structure.

Basic Information

Item	Details
Product Name	1-[2-[2-(Dimethylamino)-3-phenylpropanoylamino]-3-methylpentanoyl]-2,3,3a,13,14,15a-hexahydro-13-(1-methylpropyl)-5,8-ethenopyrrolo[3,2-b][1,5,8]oxadiazacyclotetradecine-12,15(1H,11H)-dione
CAS No.	38496-02-5
Molecular Formula	C37H49N5O5
Molecular Weight	643.82 g/mol
Synonyms	Cyclosporin G Metabolite AM1; AM1 Cyclosporin Metabolite; [D-Ser]8-Cyclosporin A; UNII-2QZ1M7P17O; 2QZ1M7P17O; Cyclosporin G, 8-(D-Ser)-; 8-(D-Ser)-Cyclosporin G; Cyclosporin G Metabolite (AM1)
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.