Description

2-Methylpropanoic acid (3aR,4R,6R,8S,9S,10Z,11aR)-8-acetoxy-2,3,3a,4,5,6,7,8,9,11a-decahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester is a high-purity, complex sesquiterpene lactone derivative with significant potential in advanced organic synthesis and pharmaceutical research. Its intricate stereochemistry and functional groups make it a valuable chiral building block for the development of novel bioactive compounds. This specialty chemical is primarily targeted at research institutions and pharmaceutical companies engaged in the synthesis of complex natural product analogs and new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new therapeutic agents, particularly in oncology and anti-inflammatory drug discovery.
• Advanced Organic Synthesis: Used as a sophisticated building block for constructing complex molecular architectures in total synthesis projects.
• Medicinal Chemistry Research: Provides a core scaffold for structure-activity relationship (SAR) studies and the generation of focused compound libraries.
• Natural Product Analog Synthesis: Enables the semi-synthesis and modification of sesquiterpene lactone-based natural products for enhanced bioactivity or stability.
• Biochemical Research: Potential use as a probe or inhibitor in studying specific biological pathways due to its complex, nature-inspired structure.

Basic Information

Product Name	2-Methylpropanoic acid (3aR,4R,6R,8S,9S,10Z,11aR)-8-acetoxy-2,3,3a,4,5,6,7,8,9,11a-decahydro-9-hydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester
CAS No.	33143-54-3
Molecular Formula	C22H30O7
Molecular Weight	406.47 g/mol
Synonyms	Isobutyric acid, 2,3,3a,4,5,6,7,8,9,11a-decahydro-8-acetoxy-9-hydroxy-6,10-dimethyl-3-methylene-2-oxo-6,9-epoxycyclodeca[b]furan-4-yl ester, (3aR,4R,6R,8S,9S,10Z,11aR)-; Parthenolide 4-Isobutyrate; 4-O-Isobutyrylparthenolide; Isobutyrylparthenolide; 4β-Isobutyryloxy-parthenolide; (10Z)-4β-Isobutyryloxy-parthenolide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). For long-term storage, consider storing under inert atmosphere at 2-8°C to maximize stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.