Description

Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- is a high-purity, complex organic compound designed for advanced pharmaceutical research and development. This molecule is of significant interest for its potential as a key intermediate or active pharmaceutical ingredient (API) in targeted therapeutic applications. It is primarily intended for use by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in the synthesis of novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of complex drug molecules, particularly in oncology and targeted therapy research.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the research and development of bifunctional molecules designed to degrade specific disease-causing proteins.
• Kinase Inhibitor Research: Acts as a precursor or core structure in the development of novel kinase inhibitors for cancer treatment.
• Preclinical & Clinical Trial Material: Supplied as a high-grade material for non-clinical studies and the manufacture of batches for early-phase clinical trials.
• Chemical Biology Probes: Utilized in academic and industrial labs to study specific biological pathways and protein functions.
• Process Chemistry & Scale-Up: Provides a defined starting point for process development and optimization towards commercial-scale API manufacturing.

Basic Information

Item	Details
Product Name	Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-
CAS No.	2519823-34-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ARV-471 derivative intermediate; PROTAC BET degrader related compound; Bivalent molecule for targeted protein degradation; (3R)-3-[[5-chloro-4-[[2-(isopropylsulfonyl)phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinepropanamide derivative; Isoindoline-1,3-dione linked acetamide; BMS-986378 related substance
EINECS	Contact for details

Quality Control

Our Acetamide, N-[7-[(3R)-3-[[5-chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data and impurity profiles are available for all shipments. We support compliance with ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. For long-term storage, consider freezing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.