Description

2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)- is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is of significant value in medicinal chemistry research and development, particularly for the synthesis of targeted therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used as a key scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Serves as a potential component in the design of bifunctional molecules for targeted protein degradation therapies.
• Kinase Inhibitor Synthesis: Employed in the construction of complex molecules designed to inhibit specific kinase enzymes involved in disease pathways.
• Preclinical Development: Supplied for the production of compounds required for pharmacological and toxicological studies.
• Contract Research & Manufacturing (CRO/CMO): Sourced by service organizations supporting pharmaceutical companies with custom synthesis and scale-up.

Basic Information

Product Name	2-Piperazineacetonitrile, 4-[7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
CAS No.	2490716-96-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2S)-4-[7-(8-Chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(4-pentyn-1-yl)-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]-1-(2-fluoro-1-oxo-2-propen-1-yl)-2-piperazineacetonitrile; (2S)-1-(2-Fluoroacryloyl)-4-[7-(8-chloronaphthalen-1-yl)-5,6,7,8-tetrahydro-2-[[(2S)-1-(pent-4-yn-1-yl)pyrrolidin-2-yl]methoxy]pyrido[3,4-d]pyrimidin-4-yl]piperazine-2-carbonitrile; UNII-9W6H8E8U4C; 2490716-96-4; (S)-1-(2-Fluoroacryloyl)-4-(7-(8-chloronaphthalen-1-yl)-2-(((S)-1-(pent-4-yn-1-yl)pyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)piperazine-2-carbonitrile
EINECS	Contact for details

Quality Control

Our 2-Piperazineacetonitrile derivative is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/UPLC) are provided for every shipment. We support development with custom purity grades and analytical method support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term storage (up to one month), the material may be kept at 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. Store in a cool, dry, well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time matches reference standard
Identification (MS)	Mass spectrum conforms to structure
Purity (HPLC)	≥95.0% (Area Percent)
Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.